Effects of Lower Tidal Volume on Ventilator-Induced Diaphragmatic Dysfunction
ثبت نشده
چکیده
1Department of pediatrics, Chonnam National University Medical School and Hospital, Republic of Korea 2College of Veterinary Medicine, Chonbuk National University, Republic of Korea 3National Institute of Animal Science, Republic of Korea 4Department of Pediatrics, KS hospital, Republic of Korea 5Institute of Animal Medicine, Gyeongsang National University, Republic of Korea 6Department of Thoracic and Cardiovascular surgery, Chonnam National University Medical School and Hospital, Republic of Korea
منابع مشابه
TLR4 signaling is activated in ventilator-induced diaphragm dysfunction in rats
Inflammation is involved in ventilator-induced diaphragm dysfunction. Toll-like receptor 4 (TLR4) is an important inflammatory factor, but it remains unclear whether TLR4 contributes to ventilator-induced diaphragm dysfunction. This study aimed to investigate the role of TLR4 signaling in ventilator-induced diaphragm dysfunction. Total 30 adult male SD rats were randomly divided into control gr...
متن کاملDiaphragmatic contraction during assisted mechanical ventilation.
Indirect evidence from airway pressure recordings in mechanically ventilated patients suggests that the diaphragm exhibits contractile activity beyond that required to trigger a ventilator-assisted breath. We used the diaphragmatic EMG to provide direct evidence of persistent contractile activity and studied the effects of alterations in ventilator-delivered flow rate and tidal volume on the du...
متن کاملLow tidal volume ventilation ameliorates left ventricular dysfunction in mechanically ventilated rats following LPS-induced lung injury
BACKGROUND High tidal volume ventilation has shown to cause ventilator-induced lung injury (VILI), possibly contributing to concomitant extrapulmonary organ dysfunction. The present study examined whether left ventricular (LV) function is dependent on tidal volume size and whether this effect is augmented during lipopolysaccharide(LPS)-induced lung injury. METHODS Twenty male Wistar rats were...
متن کاملRole of cholesterol in the biophysical dysfunction of surfactant in ventilator-induced lung injury.
Mechanical ventilation may lead to an impairment of the endogenous surfactant system, which is one of the mechanisms by which this intervention contributes to the progression of acute lung injury. The most extensively studied mechanism of surfactant dysfunction is serum protein inhibition. However, recent studies indicate that hydrophobic components of surfactant may also contribute. It was hyp...
متن کاملCritical illness and mechanical ventilation: effects on the diaphragm.
Although life-saving, mechanical ventilation is associated with numerous complications. These include pneumonia, cardiovascular compromise, barotrauma, and ventilator-induced lung injury. Recent data from animal studies suggest that controlled mechanical ventilation can cause dysfunction of the diaphragm, decreasing its force-generating capacity--a condition referred to as ventilator-induced di...
متن کامل